Op deze pagina wil ik wat meer verdieping geven op het gebied van biochemie.
Biochemie bron 1. De site van AK Lectures
Een geweldige site om meer te leren is de site van AK Lectures Ik ga hieronder enkele video’s van deze site delen maar ga naar de site voor een volledig overzicht van de vele lessen over dit onderwerp.
Biochemie bron 2. University of Hawai’i Maui College.
Onderstaande video is een goede start om de basisbegrippen uit de organische chemie te begrijpen. Het begint met wat legendes uit Hawaii maar daarna pakt hij de les toch uitstekend op naar mijn idee.
The first video is a good start for basic knowledge on chemistry in general and an introduction to biochemistry.
Deze video is van de University of Hawai’i Maui College.
Dr. Steven Farmer.
Dit is het tweede deel van deze serie waarin meer de cellen en hun processen centraal staan. Deze video is al wat moeilijker misschien is het verstandiger om eerst hieronder eens de complete biochemie lezingen van Professor Kevin Ahern te bekijken.
The second video is more complicated and you might want to look under this video and check some of the lectures from Professor Kevin Ahern.
De video hieronder is van Chris Masterjohn.
Did you know that adding MCT oil to your pasta is more ketogenic than restricting your carbohydrates to ten percent of calories?
Many people think of carbohydrate and insulin as central to ketogenesis, but the direct biochemical event that initiates ketone formation is actually the oversupply of acetyl groups to the TCA cycle during conditions of oxaloacetate depletion.
While largely a biochemistry lesson, in this video I also teach you the practical implications of this. There is more than one route to ketogenesis, and while they all produce ketones, they are fundamentally different in important ways.
Adding coconut, MCT oil, or exogenous ketones allows you to reap benefits of ketones without necessarily restricting carbohydrates and insulin, and that may be useful if you are also trying to reap some of the benefits of carbohydrate and insulin.
On the other hand, certain conditions that respond to ketogenic diets, for example refractory childhood epilepsy, need stronger degrees of ketogenesis than you can achieve simply by adding MCT oil to pasta.
Understanding the difference allows you to better make practical decisions about your diet that are most consistent with your priorities.
In this episode, you will find all of the following, and more:
An overview of the TCA cycle and burning carbohydrate for energy; the critical importance of oxaloacetate (OAA) to allow acetyl groups to enter the TCA cycle; how we burn fat on a mixed diet; the meaning of the phrase, “fat burns in the flame of carbohydrate” or “fat burns in a carbohydrate flame”; loss of lean muscle mass can occur if dietary carbohydrate and protein are too low to maintain OAA levels, and fat cannot spare this loss; under carbohydrate restriction, OAA is not repleted by carbohydrate and is used for gluconeogenesis, while more fatty acids reach the liver to make acteyl CoA; the oversupply of acetyl groups in excess of OAA initiates ketogenesis; insulin shifts fat to adipose tissue, but this doesn’t cause obesity; MCTs go straight to the liver via the portal vein rather than going to the blood via the lymph in chylomicrons, and they thereby avoid that effect of insulin; insulin suppresses the carnitine shuttle; MCTs do not require the carnitine shuttle and are therefore immune to this effect of insulin; MCTs at breakfast suppress food intake at lunch; MCTs added to pasta increase beta-hydroxybutyrate; two ways of getting ketones: selective deprivation vs. abundance; if you are trying to get ketones but having negative effects of carbohydrate restriction you can add MCTs to get the ketones; comparison of beta-hydroxybutyrate from MCT vs. 10% carb vs. classical ketogenic diet.
Oregon State University. Professor Kevin Ahern.
Meer over mittochondrieën.
Dr. Nunnari explains that mitochondria are derived from prokaryotes and played a pivotal role in the evolution of eukaryotes. In an aerobic environment, mitochondria produce energy, in the form of ATP. This energy allowed eukaryotes to develop into complex cells and organisms. Mitochondria are also fascinating because they have retained their own genome and are dynamic organelles that communicate with other compartments in the eukaryotic cell.